反应详情

2-Carboxy-5-methylpyrazine 4-oxide (2.5 g) was added to methanol (60 ml) and ethanolamine (1.1 ml). The mixture was refluxed for 20 minutes, then cooled and filtered to obtain 2-carboxy-5-methylpyrazine 4-oxide ethanolamine salt (2.1 g), m.p. 177°-180° C, after crystallisation from methanol.

1. temperatureThe mixture was refluxed for 20 minutes
2. temperaturecooled
3. filtrationfiltered