HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 2-Carboxy-5-methylpyrazine 4-oxide ethanolamine salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Acipimox | HCID 5310993 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Carboxy-5-methylpyrazine 4-oxide ethanolamine salt | HCID 21408176 | 120.3% |
Reaction Steps
2-Carboxy-5-methylpyrazine 4-oxide (2.5 g) was added to methanol (60 ml) and ethanolamine (1.1 ml). The mixture was refluxed for 20 minutes, then cooled and filtered to obtain 2-carboxy-5-methylpyrazine 4-oxide ethanolamine salt (2.1 g), m.p. 177°-180° C, after crystallisation from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002750 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-69e379b6fcd04fc388045f6b6382e596 |
| Source note | uspto-grants-1977_01 |