Potassium Carbonate → HCID 21485439, compound

HRID 1414946Notes

Reaction equation

HRID 1414946 reaction equation
[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][C:5]#[C:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]2[O:16]C[O:18][C:12]=2[CH:11]=1)[CH3:2].C(=O)([O-])[O-:22].[K+].[K+]>S(=O)(=O)(O)O>[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][C:6](=[O:22])[CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([OH:18])[CH:11]=1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21485414HCID 21485414, compound

Product 1

HCID 21485439HCID 21485439, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Add mercuric sulphate (0.27 g) to a swirled solution of 1-diethylamino-6-(3,4-methylenedioxyphenyl)hex-2-yne (3 g) in 10% aqueous sulphuric acid (15 cc) and heat the mixture for 90 minutes at 75° in an atmosphere of nitrogen. Filter the cooled reaction mixture and add solid potassium carbonate to pH 8.5. Extract the product with ether; wash and dry and evaporate the solvent to leave as residue crude 1-diethylamino-6-(3,4-dihydroxyphenyl)hexan-3-one.

Workup

  1. temperatureheat the mixture for 90 minutes at 75° in an atmosphere of nitrogen
  2. filtrationFilter
  3. customthe cooled reaction mixture
  4. extractionExtract the product with ether
  5. washwash
  6. customdry
  7. customevaporate the solvent

Sources & evidence

ORD record
ord-f29fc0978369444c8411282b9209acb8
Source dataset
uspto-grants-1977_01
Patent number
US04002746

Reaction notes

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