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Methanol → 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | HCID 21485513 | HCID 21485513 | — |
| 溶媒 | 2-Methyl-1,3-cyclopentanedione | HCID 13005 | — |
| 生成物 | 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione | HCID 20350002 | — |
反応手順
Add sodium (0.05 g) to a 0.12% methanolic potassium hydroxide solution (15 cc). To this solution add 1-bromo-6-(m-methoxyphenyl)hexan-3-one (0.9 g) in methanol (5 cc) and 2-methylcyclopentane-1,3-dione (0.4 g), and reflux the mixture for 6 hours. After working up as in the preparation of the title compound in a previous example, obtain the crude Michael adduct 2-(6-m-methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione as a yellow gum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04002746 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-b36ca9254e4e4ca58e5f55efc2d9b721 |
| 出典メモ | uspto-grants-1977_01 |