Methanol → 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione

HRID 1414953노트

반응식

HRID 1414953 반응식
[Na].[OH-:2].[K+].Br[CH2:5][CH2:6][C:7](=[O:19])[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1.[CH3:20][OH:21]>CC1C(=O)CCC1=O>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH2:10][CH2:9][CH2:8][C:7](=[O:19])[CH2:6][CH2:5][C:6]2([CH3:5])[C:7](=[O:2])[CH2:8][CH2:9][C:20]2=[O:21])[CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 14797Potassium HydroxideHCID 5360545SodiumHCID 21485513HCID 21485513, 화합물

생성물 1

HCID 203500022-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione

시약·촉매·용매 1

HCID 130052-Methyl-1,3-cyclopentanedione용매

실험 절차

Add sodium (0.05 g) to a 0.12% methanolic potassium hydroxide solution (15 cc). To this solution add 1-bromo-6-(m-methoxyphenyl)hexan-3-one (0.9 g) in methanol (5 cc) and 2-methylcyclopentane-1,3-dione (0.4 g), and reflux the mixture for 6 hours. After working up as in the preparation of the title compound in a previous example, obtain the crude Michael adduct 2-(6-m-methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione as a yellow gum.

후처리

  1. temperaturereflux the mixture for 6 hours

출처 및 근거

ORD 기록
ord-b36ca9254e4e4ca58e5f55efc2d9b721
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002746

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