HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol | HCID 101950 | — |
Reaction Steps
Add 13β-Ethyl-3-methoxy-gona-1,3,5(10)-trien-17β-ol (0.5 g.) in tetrahydrofuran (50 cc.) to stirred liquid ammonia (150 cc.), followed by lithium foil (0.5 g.) and then add ethanol (6 cc.) during 20 minutes. When the blue color is discharged, add water and work up the product with ether, to yield 13β-ethyl-3-methoxy-gona-2,5(10)-dien-17β-ol as a solid (0.47 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-117baf373e194c7e8b8a1f369b9a24c1 |
| Source note | uspto-grants-1977_01 |