HRID1414995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11143

2-Propanol, aluminum salt

C9H21AlO3

结构：CCC[C@]12CC[C@@H]3C4=C(CC[C@H]3[C@@H]1CC[C@@H]2O)CC(OC)=CC4

HCID68144248

未命名化合物

PRODUCTS

生成物

结构：CCC[C@]12CC[C@@H]3C4=C(CC[C@H]3[C@@H]1CCC2=O)CC(OC)=CC4

HCID54137482

未命名化合物

收率 67.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

溶剂HCID7967

Cyclohexanone

C6H10O

PROCEDURE

实验过程

Reflux 13β-n-propyl-3-methoxy-gona-2,5(10)-dien-17β-ol (3.0 g.) with aluminium isopropoxide in toluene and cyclohexanone according to the conditions of Oppenauer oxidation. Isolate and recrystallize the product from methanol to give 13β-n-propyl-3-methoxy-gona-2,5(10)-dien-17-one (2.0 g.), m.p. 128°-31° C. with softening at 125°.

WORKUP

后处理

customIsolate
customrecrystallize the product from methanol