HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum isopropoxide → 3-Methoxy-13-propylgona-2,5(10)-dien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum isopropoxide | HCID 11143 | — |
| Reactant | 13beta-n-Propyl-3-methoxy-gona-2,5(10)-dien-17beta-ol | HCID 68144248 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Cyclohexanone | HCID 7967 | — |
| Product | 3-Methoxy-13-propylgona-2,5(10)-dien-17-one | HCID 54137482 | 67.1% |
Reaction Steps
Reflux 13β-n-propyl-3-methoxy-gona-2,5(10)-dien-17β-ol (3.0 g.) with aluminium isopropoxide in toluene and cyclohexanone according to the conditions of Oppenauer oxidation. Isolate and recrystallize the product from methanol to give 13β-n-propyl-3-methoxy-gona-2,5(10)-dien-17-one (2.0 g.), m.p. 128°-31° C. with softening at 125°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-26db2dfa1a554cbab259264f3476f516 |
| Source note | uspto-grants-1977_01 |