Hydrochloric Acid → 1-[2-(4-Amino-1-piperidinyl)ethyl]-7-fluoro-2(1H)-quinolinone

HRID 141500Notes

Reaction equation

[CH3:34][OH:35].[CH:29]([Cl:30])([Cl:31])[Cl:32].[ClH:33].[F:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1>>[F:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]3)[c:10]2[cH:11]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 6212Chloroform

HCID 86635312tert-Butyl {1-[2-(7-fluoro-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667744061-[2-(4-Amino-1-piperidinyl)ethyl]-7-fluoro-2(1H)-quinolinone

Sources & evidence

ORD record: ord-d8127434d5974c5cbd4eb660d3547539
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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