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HRID1415058

反应详情

EQUATION

反应方程式

HRID 1415058 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)N(C)C
HCID31374

Dimethylacetamide

C4H9NO

结构：COc1ccc2c(c1)CCC1=C2CC[C@]2(C)C(=O)CC[C@@H]12
HCID11055125

未命名化合物

PRODUCTS

生成物

1
结构：C#C[C@]1(O)CC[C@H]2C3=C(CC[C@@]21C)c1ccc(OC)cc1CC3
HCID86733491

19-Norpregna-1,3,5(10),8-tetraen-20-yn-17-ol, 3-methoxy-, (17α)-(±)-

C21H24O2

PROCEDURE

实验过程

Add solid lithium acetylide-ethylenediamine complex (9.5 g) to 3-methoxyestra-1,3,5(10),8-tetraen-17-one (10 g) in dimethylacetamide (100 ml), stir the mixture for 15 hours and then pour into ice water. Extract with ether-benzene (1:1), and wash, dry and evaporate the organic extract. Recrystallize the residue from methanol to obtain dl-17α-ethynyl-3-methoxyestra-1,3,5(10),8-tetraen-17-ol (2.8 g), m.p. 133°-137°; infrared absorption peaks at 3.1 μ, 6.25 μ.

WORKUP

后处理

  1. extractionExtract with ether-benzene (1:1)
  2. washwash
  3. customdry
  4. customevaporate the organic extract
  5. customRecrystallize the residue from methanol