Hydrochloric Acid → Sulfuric acid--6-(morpholin-4-yl)pyrimidine-2,4,5-triamine (1/1)

HRID 1415077Notes

Reaction equation

HRID 1415077 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:9]=[O:10])=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[N:3]=1.Cl.S([S:21]([O-:23])=[O:22])([O-])=O.[Na+].[Na+].[OH2:26]>>[S:21]([OH:23])([OH:10])(=[O:22])=[O:26].[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[C:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[N:3]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 24489Sodium DithioniteHCID 20376074HCID 20376074, compound

Product 1

HCID 70586678Sulfuric acid--6-(morpholin-4-yl)pyrimidine-2,4,5-triamine (1/1)

Conditions

Temperature
50 °C

Procedure

2.5 gm of 2,4-diamino-6-morpholino-5-nitroso-pyrimidine was suspended in 15 ml of water, and 2 N HCl (5 ml) was added until the substance just dissolved. The mixture was heated to 50° C; and sodium dithionite (Na2S2O4) was added until the violet color solution took on a yellow color. Then, the solution was filtered, cooled, and adjusted to a pH 2 by means of sulfuric acid (1 : 1). After a short time, the pyrimidine derivative precipitated as pyrimidine sulfate; the yield was 2.6 gm which was 76.4% of theory.

Workup

  1. dissolutionjust dissolved
  2. filtrationThen, the solution was filtered
  3. temperaturecooled
  4. customAfter a short time, the pyrimidine derivative precipitated as pyrimidine sulfate

Sources & evidence

ORD record
ord-67808618b2f748d2ae141c2df0ee0c36
Source dataset
uspto-grants-1977_01
Patent number
US04003699

Reaction notes

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