Hydrochloric Acid → HCID 5245795, compound

Participants

Reaction Steps

A suspension of 5.0 g. (0.02 mole) of 5-phenyl-3-(4-nitrophenyl)-1,2,4-oxadiazole, from part (a), in 200 ml. of 95% ethanol containing 0.5 g. of 5% Pd/C and 3ml. of concentrated HCl is hydrogenated on the Parr hydrogenator at 50 psi. over a period of 1 hour. The catalyst is removed by filtration followed by removal of the ethanol by distillation in vacuo to yield the 5-phenyl-3-(4-aminophenyl)-1,2,4-oxadiazole.

Provenance & Evidence