Hydrochloric Acid → HCID 5245795, compound

HRID 1415130Notes

Reaction equation

HRID 1415130 reaction equation
[C:1]1([C:7]2[O:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>[Pd].C(O)C>[C:1]1([C:7]2[O:11][N:10]=[C:9]([C:12]3[CH:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 6224843-(4-Nitrophenyl)-5-phenyl-1,2,4-oxadiazole

Product 1

HCID 5245795HCID 5245795, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 5.0 g. (0.02 mole) of 5-phenyl-3-(4-nitrophenyl)-1,2,4-oxadiazole, from part (a), in 200 ml. of 95% ethanol containing 0.5 g. of 5% Pd/C and 3ml. of concentrated HCl is hydrogenated on the Parr hydrogenator at 50 psi. over a period of 1 hour. The catalyst is removed by filtration followed by removal of the ethanol by distillation in vacuo to yield the 5-phenyl-3-(4-aminophenyl)-1,2,4-oxadiazole.

Workup

  1. additionA suspension of 5.0 g
  2. customThe catalyst is removed by filtration
  3. customfollowed by removal of the ethanol by distillation in vacuo

Sources & evidence

ORD record
ord-7a5e043949ff46659ff026fccffeedd4
Source dataset
uspto-grants-1977_01
Patent number
US04003909

Reaction notes

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