Hydrochloric Acid → HCID 21483715, compound

HRID 1415132Notes

Reaction equation

HRID 1415132 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[N:8]=1.Cl>[Pd].C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[N:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19658057HCID 19658057, compound

Product 1

HCID 21483715HCID 21483715, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2.68 g. (0.01 mole) of 5-(2-pyridyl)-3-(4-nitrophenyl)-1,2,4-oxadiazole, from part (a), 10 ml. of 10% HCl, 190 ml. of absolute ethanol, and 0.27 g. of 5% Pd/C is reduced on the Parr hydrogenator at 50 psi. until the required amount of hydrogen is absorbed. The catalyst is removed by filtration followed by removal of the ethanol by distillation in vacuo to yield the 5-(2-pyridyl)-3-(4-aminophenyl)-1,2,4-oxadiazole.

Workup

  1. additionA mixture of 2.68 g
  2. customuntil the required amount of hydrogen is absorbed
  3. customThe catalyst is removed by filtration
  4. customfollowed by removal of the ethanol by distillation in vacuo

Sources & evidence

ORD record
ord-8bc6ccb7d8e348fcaf2fb7dd157d138b
Source dataset
uspto-grants-1977_01
Patent number
US04003909

Reaction notes

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