Acetaldehyde → HCID 53975926, compound

HRID 1415280Notes

Reaction equation

HRID 1415280 reaction equation
[PH3]=O.[CH3:3][P:4]([CH3:8])[O:5]CC.[CH:9](=O)[CH3:10].[NH2:12][C:13]([NH2:15])=[O:14].B(F)(F)F.CCOCC>>[CH3:3][P:4](=[O:5])([CH3:8])[CH:9]([NH:12][C:13]([NH2:15])=[O:14])[CH3:10]

Participants

6

Reactant 5

HCID 177AcetaldehydeHCID 1176UreaHCID 8000Boron trifluoride etherateHCID 22354332HCID 22354332, compoundHCID 178527022HCID 178527022, compound

Product 1

HCID 53975926HCID 53975926, compound

Procedure

This example shows the preparation of a phosphine oxide, that is a compound containing three P--C bonds. Warming (50°-100° C) of a mixture of ethyl dimethylphosphinite, acetaldehyde and urea in the presence of a catalytic amount of boron trifluoride etherate gives dimethyl (1-ureidoethyl)phosphine oxide, a product that cannot be hydrolyzed to an acid of phosphorus.

Workup

  1. additioncontaining three P
  2. temperatureWarming

Sources & evidence

ORD record
ord-6d68346b01e647beaaea663d26a3839e
Source dataset
uspto-grants-1977_01
Patent number
US04003965

Reaction notes

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