反应详情

A cold solution (10° C.) of sodium acetylsalicylate was prepared by adding 34.6 gms. of sodium carbonate hydrate and 100 gms. of aspirin to 600 ml. of distilled water stirring until all solids had dissolved and using an additional 320 ml. of distilled water to wash down the walls of the container. Twenty-five gms. of instant tea was added with stirring until the tea dissolved. To 750. ml. of cold distilled water (5° C.) was added 250 ml. of the aspirin-tea solution and 20 ml. of glacial acetic acid. After a period of one hour the remaining aspirin-tea solution was added in 50 ml. portions with glacial acetic acid being added after each addition, the first amount being 4.0 ml. and increasing each addition by 1.0 ml.; a stirring period of 10 minutes occurred between each addition. The coprecipitate was allowed to settle, the supernatant was decanted, the coprecipitate was washed with glycine buffer solution and collected by filtration. After air drying, the product weighted 79.2 gms. Analysis of the coprecipitate showed it contained 95.3% aspirin, 4.17% tea constituent, 0.03% salicylic acid and 0.50% water.

1. additionby adding 34.6 gms
2. washof distilled water to wash down the walls of the container
3. additionof instant tea was added
4. dissolutiondissolved
5. distillationof cold distilled water (5° C.)
6. additionwas added 250 ml
7. additionAfter a period of one hour the remaining aspirin-tea solution was added in 50 ml
8. additionportions with glacial acetic acid being added
9. additionafter each addition
10. temperatureand increasing
11. additioneach addition by 1.0 ml
12. additiona stirring period of 10 minutes occurred between each addition
13. customthe supernatant was decanted
14. washthe coprecipitate was washed with glycine buffer solution
15. filtrationcollected by filtration
16. customAfter air drying