HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1415288Generated: November 1, 2026
Water → 4-Chloro-5-(1-methylhydrazinyl)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone
https://huagongshe.com/reaction/1415288
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | 4,5-Dichloro-2-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one | HCID 826560 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-5-(1-methylhydrazinyl)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone | HCID 21484110 | — |
Reaction Steps
To a solution consisting of 15.5 grams of 4,5-dichloro-2-(3-trifluoromethylphenyl)-3(2H)-pyridazinone in 120 grams of methanol is added 9.2 grams methylhydrazine. The reaction mixture is heated to 45° C. for 3 hours, cooled and poured onto 250 grams of water. The resulting precipitate is separated by filtration, washed with water and dried. The solid is crystallized from benzene to yield 4-chloro-5-(1-methylhydrazino)-2-(3'-trifluoromethylphenyl)-3-(2H)-pyridazinone. (m.p. 140° to 141° C. with decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04004009 |
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| Source dataset | uspto-grants-1977_01 |
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| ORD ID | ord-1a065bd70b3a4915bce1ef0869822abc |
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| Source note | uspto-grants-1977_01 |
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