Benzene, 1-nitro-4-[(3-phenylpropyl)thio]- → 4-(3'-Phenyl-propylthio)-aniline

HRID 1415346Notes

Reaction equation

HRID 1415346 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Ni].CN(C)C=O>[C:1]1([CH2:7][CH2:8][CH2:9][S:10][C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 11311846Benzene, 1-nitro-4-[(3-phenylpropyl)thio]-

Product 1

HCID 214818444-(3'-Phenyl-propylthio)-aniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 6228DimethylformamideSolvent

Procedure

90 g of 4-(3'-phenyl-propylthio)-nitrobenzene is catalytically hydrogenated in 300 ml. of dimethylformamide with Raney nickel. After completion of the hydrogen absorption and removal of the catalyst and the solvent, there is obtained 4-(3'-phenyl-propylthio)-aniline as an oily residue, which can be used without purification in the next reaction stage.

Workup

  1. customAfter completion of the hydrogen absorption and removal of the catalyst

Sources & evidence

ORD record
ord-8f76f327261948b3a832277113c2bbc7
Source dataset
uspto-grants-1977_01
Patent number
US04004907

Reaction notes

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