反应详情

A total of 32 g of isobutylmalonic acid was boiled under reflux with 60 g of 5-indanol and 60 g of phosphorus pentoxide in 1000 ml of toluene. The solution was decanted from undissolved material and evaporated under reduced pressure. The brownish oily residue was chromatographed on a column of silica gel with benzene as the eluant. After evaporation under reduced pressure, the fractions containing the desired compound yielded 26.0 g of a light oil which crystallizes on standing to yield isobutylmalonic acid di-5-indanyl ester.

1. customThe solution was decanted from undissolved material
2. customevaporated under reduced pressure
3. customThe brownish oily residue was chromatographed on a column of silica gel with benzene as the eluant
4. customAfter evaporation under reduced pressure
5. additionthe fractions containing the desired compound
6. customyielded 26.0 g of a light oil which
7. customcrystallizes