Phosphorus oxide (P4O10) → Isobutylmalonic acid di-5-indanyl ester

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A total of 32 g of isobutylmalonic acid was boiled under reflux with 60 g of 5-indanol and 60 g of phosphorus pentoxide in 1000 ml of toluene. The solution was decanted from undissolved material and evaporated under reduced pressure. The brownish oily residue was chromatographed on a column of silica gel with benzene as the eluant. After evaporation under reduced pressure, the fractions containing the desired compound yielded 26.0 g of a light oil which crystallizes on standing to yield isobutylmalonic acid di-5-indanyl ester.

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