Picolinic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]pyridine-2-carboxamide
Reaction equation
[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1.[OH:19][C:20](=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:20](=[O:19])[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1Participants
3
Sources & evidence
- ORD record
- ord-e91dc3252378437493c361546f646735
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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