Methanol → HCID 57124056, compound

HRID 1415423Notes

Reaction equation

HRID 1415423 reaction equation
[CH:1]1([C:4](=O)[CH:5]=[CH:6][C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[CH2:3][CH2:2]1.[N+:18]([CH2:21][CH3:22])([O-:20])=[O:19].[Na].C[OH:25]>>[CH:1]1([CH2:4][C:5](=[O:25])[CH:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[CH:21]([N+:18]([O-:20])=[O:19])[CH3:22])[CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 887MethanolHCID 6587NitroethaneHCID 5360545SodiumHCID 54569356HCID 54569356, compound

Product 1

HCID 57124056HCID 57124056, compound

Procedure

The procedure of Example IX using 36 g of 1-cyclopropyl-3-(m-trifluoromethylphenyl)prop-2-en-1-one, 14 ml of nitroethane and 1.85 g of sodium in 150 ml of methanol gives 36 g of 1-cyclopropyl-3-(m-trifluoromethylphenyl)-4-nitropentanone as an oily residue which is used in the crude state for the remainder of the operations.

Sources & evidence

ORD record
ord-46d14f2a6ced45fb941eb3f80f64ccc9
Source dataset
uspto-grants-1977_01
Patent number
US04005103

Reaction notes

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