Piperidine → HCID 21482759, compound

HRID 1415509Notes

Reaction equation

HRID 1415509 reaction equation
ClC1N=NC(Cl)=[C:4]2[CH:9]=[N:10][C:11](C3C=CC(O)=CC=3)=[CH:12][C:3]=12.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:51]=[CH:50][C:43]3=[C:44](Cl)[N:45]=[N:46][C:47](Cl)=[C:42]3[CH:41]=2)=[CH:36][CH:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:51]=[CH:50][C:43]3=[C:44]([N:10]4[CH2:11][CH2:12][CH2:3][CH2:4][CH2:9]4)[N:45]=[N:46][C:47]([N:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)=[C:42]3[CH:41]=2)=[CH:36][CH:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 21482760HCID 21482760, compoundHCID 135698448HCID 135698448, compound

Product 1

HCID 21482759HCID 21482759, compound

Procedure

In a procedure similar to (1) in Example 2, 7.0 g. of piperidine instead of morpholine is reacted with 1.7 g. of 7-(4-benzyloxyphenyl)-1,4-dichloropyrido(3,4-d)pyridazine, whereby 1.2 g. of 7-(4-benzyloxyphenyl)-1,4-dipiperidinopyrido(3,4-d)pyridazine is obtained.

Sources & evidence

ORD record
ord-481f4e8e4e7b410ca594727798504230
Source dataset
uspto-grants-1977_01
Patent number
US04005201

Reaction notes

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