反应详情

A mixture of 10 g. of 3-aminopiperidine and 29.6 g. of phthalic anhydride is heated at 150° C. for 30 minutes. This mixture which contains 1-(2-carboxybenzoyl)-3-phthalimidopiperidine is heated at reflux with 500 ml. of 6N hydrochloric acid for two hours. The aqueous phase is extracted with ether and then concentrated in vacuo. The residue is extracted with dilute aqueous sodium hydroxide solution and methylene chloride. The organic phase is dried and concentrated in vacuo to give 3-phthalimidopiperidine.

1. additionA mixture of 10 g
2. temperatureis heated
3. temperatureat reflux with 500 ml
4. extractionThe aqueous phase is extracted with ether
5. concentrationconcentrated in vacuo
6. extractionThe residue is extracted with dilute aqueous sodium hydroxide solution and methylene chloride
7. customThe organic phase is dried
8. concentrationconcentrated in vacuo