反应详情

A mixture of 11.5 g. of 3-phthalimidopiperidine and 2.85 g. of methyl isocyanate in 100 ml. of dry benzene is stirred at 25° C. for 2 hours. The resulting mixture is concentrated in vacuo and filtered to give 1-(N-methylcarbamoyl)-3 -phthalimidopiperidine. Treating this phthalimidopiperidine with hydrazine hydrate by the procedure of Example 17 gives 1-(N-methylcarbamoyl)-3-aminopiperidine.

1. additionA mixture of 11.5 g
2. concentrationThe resulting mixture is concentrated in vacuo
3. filtrationfiltered