HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 1-(N-methylcarbamoyl)-3-phthalimidopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-(Piperidin-3-yl)-1H-isoindole-1,3(2H)-dione | HCID 19972263 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-(N-methylcarbamoyl)-3-phthalimidopiperidine | HCID 21482872 | — |
Reaction Steps
A mixture of 11.5 g. of 3-phthalimidopiperidine and 2.85 g. of methyl isocyanate in 100 ml. of dry benzene is stirred at 25° C. for 2 hours. The resulting mixture is concentrated in vacuo and filtered to give 1-(N-methylcarbamoyl)-3 -phthalimidopiperidine. Treating this phthalimidopiperidine with hydrazine hydrate by the procedure of Example 17 gives 1-(N-methylcarbamoyl)-3-aminopiperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04005208 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-c7f55a5ee22f4b9682a3af218dd63c7c |
| Source note | uspto-grants-1977_01 |