Phthalimide → HCID 21482269, compound

HRID 1415603Notes

Reaction equation

HRID 1415603 reaction equation
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27](=[O:47])[C:28]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=1[N:35]1[C:39]([CH2:40]O)=[C:38]([CH3:42])[N:37]=[C:36]1[CH2:43][N:44]([CH3:46])[CH3:45].[C:48]1(=[O:58])[NH:52][C:51](=[O:53])[C:50]2=[CH:54][CH:55]=[CH:56][CH:57]=[C:49]12.N(C(OCC)=O)=NC(OCC)=O>>[F:34][C:32]1[CH:31]=[CH:30][C:29]([N:35]2[C:39]([CH2:40][N:52]3[C:48](=[O:58])[C:49]4=[CH:57][CH:56]=[CH:55][CH:54]=[C:50]4[C:51]3=[O:53])=[C:38]([CH3:42])[N:37]=[C:36]2[CH2:43][N:44]([CH3:45])[CH3:46])=[C:28]([C:27](=[O:47])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[Cl:20])[CH:33]=1

Participants

4

Reactant 3

HCID 6809PhthalimideHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21482323HCID 21482323, compound

Product 1

HCID 21482269HCID 21482269, compound

Procedure

In the manner given in Example 3, 2'-chloro-5-fluoro-2-[2-[(dimethylamino)methyl]-4-methyl-5-hydroxymethylimidazol-1-yl]benzophenone triphenylphosphine, phthalimide and thereafter diethyl azodicarboxylate are reacted together to give N-[[1-[4-fluoro-2-(o-chlorobenzoyl)-phenyl]-2-[(dimethylamino)methyl]-4-methylimidazol-5-yl]-methyl]phthalimide.

Sources & evidence

ORD record
ord-3c833aa3ca99440c9da1ea3f9fc6f66e
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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