Hydrazine hydrate (1:1) → HCID 21482276, compound

HRID 1415612Notes

Reaction equation

HRID 1415612 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][N:14]3C(=O)C4=CC=CC=C4[C:15]3=O)=[CH:11][N:10]=[C:9]2[CH2:25][N:26]([CH3:28])[CH3:27])=[C:4](C(=O)C2C=CC=CC=2F)[CH:3]=1.O.NN>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:8]3[C:9]([CH2:25][N:26]([CH3:27])[CH3:28])=[N:10][CH:11]=[C:12]3[CH2:13][N:14]=[C:15]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[C:6]=2[CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21482275HCID 21482275, compound

Product 1

HCID 21482276HCID 21482276, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 4, N-[[1-[4-fluoro-2-(o-fluorobenzoyl)phenyl]-2-[(dimethylamino)methyl]-imidazol-5-yl]methyl]phthalimide in ethanol is heated with hydrazine hydrate to give 8-fluoro-6-(o-fluorophenyl)-1-[(dimethylamino)methyl]-4H-imidazo[1,5-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-583f67f0bd134475b9a5c00dd2f2fdb8
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

Loading…