Hydrazine hydrate (1:1) → HCID 21482303, compound

HRID 1415613Notes

Reaction equation

HRID 1415613 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][N:14]3C(=O)C4=CC=CC=C4C3=O)=[CH:11][N:10]=[C:9]2[CH2:25][N:26]([CH3:28])[CH3:27])=[C:4]([C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=2)=O)[CH:3]=1.O.NN>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]3[C:9]([CH2:25][N:26]([CH3:28])[CH3:27])=[N:10][CH:11]=[C:12]3[CH2:13][N:14]=[C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21482283HCID 21482283, compound

Product 1

HCID 21482303HCID 21482303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 4, N-[[1-[4-bromo2-(2-pyridylcarbonyl)phenyl]-2-[(dimethylamino)methyl]-imidazol-5-yl]methyl]phthalimide in ethanol is heated with hydrazine hydrate to give 8-bromo-6-(2-pyridyl)-1-[(dimethylamino)methyl]-4H-imidazo[1,5-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-a5e92f7c43be4ccfb8e3cffec427e508
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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