Ethanol → HCID 21482291, compound

HRID 1415615Notes

Reaction equation

HRID 1415615 reaction equation
[F:1][C:2]([F:40])([F:39])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([CH2:14][N:15]3C(=O)C4=CC=CC=C4[C:16]3=O)=[C:12]([CH3:26])[N:11]=[C:10]2[CH2:27][N:28]([CH3:30])[CH3:29])=[C:5](C(C2C=CC=CN=2)=O)[CH:4]=1.O.NN.[CH2:44](O)[CH3:45]>>[F:1][C:2]([F:40])([F:39])[C:3]1[CH:4]=[CH:5][C:6]2[N:9]3[C:10]([CH2:27][N:28]([CH3:30])[CH3:29])=[N:11][C:12]([CH3:26])=[C:13]3[CH2:14][N:15]=[C:16]([C:45]3[CH:44]=[CH:4][CH:5]=[CH:6][N:9]=3)[C:7]=2[CH:8]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 21482280HCID 21482280, compound

Product 1

HCID 21482291HCID 21482291, compound

Procedure

In the manner given in Example 4, N-[[1-[4-trifluoromethyl-2-(2-pyridylcarbonyl)phenyl]-2-[(dimethylamino)-methyl]-4-methylimidazol-5-yl]methyl]phthalimide in ethanol is heated with hydrazine hydrate to give 8-trifluoromethyl-6-(2-pyridyl)-1-[(dimethylamino)methyl]-3-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-c9cbbf50610a47b7bdd5d99d3b6c6429
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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