Hydrazine hydrate (1:1) → HCID 21482289, compound

HRID 1415619Notes

Reaction equation

HRID 1415619 reaction equation
[Cl:1][C:2]1[C:3]([C:30](=O)[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)=[C:4]([N:8]2[C:12]([CH2:13][N:14]3C(=O)C4=CC=CC=C4C3=O)=[C:11]([CH3:25])[N:10]=[C:9]2[CH2:26][N:27]([CH3:29])[CH3:28])[CH:5]=[CH:6][CH:7]=1.O.NN>C(O)C>[Cl:1][C:2]1[C:3]2[C:30]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)=[N:14][CH2:13][C:12]3[N:8]([C:9]([CH2:26][N:27]([CH3:29])[CH3:28])=[N:10][C:11]=3[CH3:25])[C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21482278HCID 21482278, compound

Product 1

HCID 21482289HCID 21482289, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 4, N-[[1[3-chloro-2-(p-fluorobenzoyl)phenyl]-2-[(dimethylamino)methyl]-4-methylimidazol-5-yl]methyl]phthalimide in ethanol is heated with hydrazine hydrate to give 7-chloro-6-(p-fluorophenyl)-1-[(dimethylamino)methyl]-3-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-7d49de8e26594407a6efc510d503a8fd
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

Loading…