反应详情

温度

25 °C

Concentrated hydrochloric acid (3 ml) was added dropwise to a stirred suspension of 1-methoxycarbonyl-3-(2-aminophenyl)thiourea in dry dioxan (75 ml), the temperature of the reaction mixture being maintained at 20°-25° C. during the addition by slight external cooling. The clear solution obtained was stirred for a further 30 minutes at 25° C. during which time a solid separated. This was filtered off, washed with acetone and recrystallised from ethanol to give 1-methoxycarbonyl-3-(2-aminophenyl)thiourea hydrochloride (5.1 g), m.p. 176°-178° C. (with decomposition).

1. temperaturethe temperature of the reaction mixture being maintained at 20°-25° C. during the addition by slight external cooling
2. customThe clear solution obtained
3. customseparated
4. filtrationThis was filtered off
5. washwashed with acetone
6. customrecrystallised from ethanol