HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetyl bromide → N-(4-isopropoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | 4-Isopropoxycarbonylamino-2-nitroaniline | HCID 12678037 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(4-isopropoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide | HCID 21483033 | — |
Reaction Steps
Bromoacetyl bromide (18.6 g) was added dropwise with stirring to a solution of 4-isopropoxycarbonylamino-2-nitroaniline (22g) in toluene (300 ml). The solution was refluxed for 1 hour, cooled, and the solid filtered off and recrystallised from benzene to give N-(4-isopropoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide (20 g), m.p. 195°-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04005217 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-56c4ff46aca943199cdfedec9b678a34 |
| Source note | uspto-grants-1977_01 |