反应详情

Bromoacetyl bromide (18.6 g) was added dropwise with stirring to a solution of 4-isopropoxycarbonylamino-2-nitroaniline (22g) in toluene (300 ml). The solution was refluxed for 1 hour, cooled, and the solid filtered off and recrystallised from benzene to give N-(4-isopropoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide (20 g), m.p. 195°-197° C.

1. temperatureThe solution was refluxed for 1 hour
2. temperaturecooled
3. filtrationthe solid filtered off
4. customrecrystallised from benzene