反应详情

N-(2-Nitrophenyl)-2-chloroacetamide (32.2 g) was dissolved in benzene (350 ml) and N-n-butylmethylamine (26.1 g) added. The mixture was boiled under reflux for 22 hours, the benzene evaporated off, and water (300 ml) added. The mixture was extracted with diethyl ether (3 × 200 ml), the extract dried with magnesium sulphate, filtered, and the ether evaporated off to give N-(2-nitrophenyl)-2-(N-n-butyl-N-methylamino)acetamide as a yellow oil which was used in the next stage without purification.

1. temperatureunder reflux for 22 hours
2. customthe benzene evaporated off
3. additionwater (300 ml) added
4. extractionThe mixture was extracted with diethyl ether (3 × 200 ml)
5. dry with materialthe extract dried with magnesium sulphate
6. filtrationfiltered
7. customthe ether evaporated off