N-Methylbutylamine → N-(2-nitrophenyl)-2-(N-n-butyl-N-methylamino)acetamide

Participants

Reaction Steps

N-(2-Nitrophenyl)-2-chloroacetamide (32.2 g) was dissolved in benzene (350 ml) and N-n-butylmethylamine (26.1 g) added. The mixture was boiled under reflux for 22 hours, the benzene evaporated off, and water (300 ml) added. The mixture was extracted with diethyl ether (3 × 200 ml), the extract dried with magnesium sulphate, filtered, and the ether evaporated off to give N-(2-nitrophenyl)-2-(N-n-butyl-N-methylamino)acetamide as a yellow oil which was used in the next stage without purification.

Provenance & Evidence