反应详情

A solution of 4-n-butyl-2-nitroaniline (29.1 g) in toluene (100 ml) was treated with bromoacetyl bromide (33.3 g). The mixture was boiled under reflux for 3/4 hour and the toluene evaporated off. The residual oil was poured into petroleum spirit (b.p. 60°-80° C; 400 ml). Crystals were deposited and these were removed by filtration to give N-(4-n-butyl-2-nitrophenyl)-2-bromoacetamide (41 g), m.p. 56°-57° C.

1. temperatureunder reflux for 3/4 hour
2. customthe toluene evaporated off
3. additionThe residual oil was poured into petroleum spirit (b.p. 60°-80° C; 400 ml)
4. customthese were removed by filtration