反应详情

N-(4-methoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide (25 g) in ethanol (250 ml) was treated with a solution of dimethylamine in ethanol (35.5 g of a 30% w/w solution) and the mixture refluxed for one hour. The ethanol was evaporated and the residual solid shaken with water and filtered to give N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide (21.1 g), m.p. 186°-189° C.

1. temperaturerefluxed for one hour
2. customThe ethanol was evaporated
3. filtrationfiltered