HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-(4-methoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide | HCID 21483050 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide | HCID 21483074 | — |
Reaction Steps
N-(4-methoxycarbonylamino-2-nitrophenyl)-2-bromoacetamide (25 g) in ethanol (250 ml) was treated with a solution of dimethylamine in ethanol (35.5 g of a 30% w/w solution) and the mixture refluxed for one hour. The ethanol was evaporated and the residual solid shaken with water and filtered to give N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide (21.1 g), m.p. 186°-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04005217 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-420ed934046143fc8baee747c635ed33 |
| Source note | uspto-grants-1977_01 |