反应详情

温度

5 °C

Methyl chloroformate (34 g) was added dropwise with stirring to a mixture of 2-nitro-p-phenylenediamine (50 g), sodium bicarbonate (44.5 g) and water (700 ml). The temperature was maintained at 5° C. during the addition by means of external cooling. After the addition was complete the mixture was allowed to warm to room temperature and the stirring was continued for two hours. The solid was filtered off and recrystallised from isopropanol to give 4-methoxycarbonylamino-2-nitroaniline (50 g), m.p. 171°-172° C.

1. additionAfter the addition
2. temperatureto warm to room temperature
3. filtrationThe solid was filtered off
4. customrecrystallised from isopropanol