Hydrogen Peroxide → HCID 88281291, compound

HRID 1415664Notes

Reaction equation

HRID 1415664 reaction equation
[Cl:1][C:2]1[C:7]([N:8]([CH3:18])[C:9](=[O:17])[C:10]2[CH:15]=[CH:14][CH:13]=[N:12][C:11]=2[CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:19]O>C(O)(=O)C>[Cl:1][C:2]1[C:7]([N+:8]([O-:19])([CH3:18])[C:9](=[O:17])[C:10]2[CH:15]=[CH:14][CH:13]=[N:12][C:11]=2[CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 54348185HCID 54348185, compound

Product 1

HCID 88281291HCID 88281291, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of N-(2-chloro-3-pyridinyl)-N-methyl-2-methylnicotinamide (1.86 g) and H2O2 (30%, 5 mL) in acetic acid (10 mL) was heated at 110° C. for 75 minutes. The solvents were evaporated under reduced pressure. Chromatography of the residue over basic alumina (chloroform/ethanol) gave N-(2-chloro-3-pyridinyl)-N-methyl-2-methylnicotinamide N-oxide as an oil which crystallized on trituration with isopropyl ether/ethyl acetate, (1.42 g).

Workup

  1. customThe solvents were evaporated under reduced pressure

Sources & evidence

ORD record
ord-104277a1d80d49b4a7bd1eed48575a9d
Source dataset
uspto-grants-1999_06
Patent number
US05908841

Reaction notes

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