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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1415674Generated: October 26, 2026

Benzyl piperazin-1-ylacetate → benzyl 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetate

https://huagongshe.com/reaction/1415674

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl piperazin-1-ylacetateHCID 18423308—
Reactant4-BOC-amidinobenzamidoacetic acidHCID 86754082—
Productbenzyl 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetateHCID 86754081—

Reaction Steps

4-(4-Amidinobenzamidoacetyl)piperazin-1-ylacetic acid, FAB 348, is obtained analogously from 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetic acid (FAB 448; obtainable by condensing 4-BOC-amidinobenzamidoacetic acid with benzyl piperazin-1-ylacetate to give benzyl 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetate and hydrogenolyzing the benzyl ester group).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05908843
Source datasetuspto-grants-1999_06
ORD IDord-8d7bca2b674147d3962ca1e32a2d007b
Source noteuspto-grants-1999_06