反应详情

To 300 mL of pyridine was added a-bromoacetophenone (150 g, 750 mmol) and thiophenol (83 g, 750 mmol). The mixture was heated at reflux for six hours. The pyridine was evaporated and the residue dissolved in ethyl acetate. The ethyl acetate solution was washed exhaustively with 1 N sodium hydroxide, then with 1 N hydrochloric acid, dried over magnesium sulfate, filtered, and evaporated to yield a brown oil. The product was crystallized from ethanol at 0° C. to yield 116 g of the title compound.

1. temperatureThe mixture was heated
2. temperatureat reflux for six hours
3. customThe pyridine was evaporated
4. dissolutionthe residue dissolved in ethyl acetate
5. washThe ethyl acetate solution was washed exhaustively with 1 N sodium hydroxide
6. dry with materialwith 1 N hydrochloric acid, dried over magnesium sulfate
7. filtrationfiltered
8. customevaporated
9. customto yield a brown oil
10. customThe product was crystallized from ethanol at 0° C.