Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | Methyl 2-Amino-4-bromobenzoate | HCID 17871390 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 70112915 | HCID 70112915 | — |
Reaction Steps
A solution of methyl 2-amino-4-bromo-benzoate (460 mg; 2 mmol), 2-chloronicotinic acid (315 mg; 2 mmol), concentrated hydrochloric acid (5 drops), ethanol (5 ml) and water (25 ml) was heated at reflux for 18 hours, cooled to 0° C. and filtered. The solid filter cake obtained was dried in vacuo and used directly in the next example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05908840 |
|---|
| Source dataset | uspto-grants-1999_06 |
|---|
| ORD ID | ord-9c5abeadf0f5455a86ddf472e458a7d2 |
|---|
| Source note | uspto-grants-1999_06 |
|---|
