Ethanol → HCID 70112915, compound

HRID 1415699Notes

Reaction equation

HRID 1415699 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]([Br:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.Cl[C:14]1[N:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([OH:18])=[O:17].C(O)C>Cl.O>[Br:12][C:10]1[CH:11]=[C:2]2[C:3]([C:4](=[O:6])[N:22]3[CH:21]=[CH:20][CH:19]=[C:15]([C:16]([OH:18])=[O:17])[C:14]3=[N:1]2)=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 762582-Chloronicotinic acidHCID 17871390Methyl 2-Amino-4-bromobenzoate

Product 1

HCID 70112915HCID 70112915, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A solution of methyl 2-amino-4-bromo-benzoate (460 mg; 2 mmol), 2-chloronicotinic acid (315 mg; 2 mmol), concentrated hydrochloric acid (5 drops), ethanol (5 ml) and water (25 ml) was heated at reflux for 18 hours, cooled to 0° C. and filtered. The solid filter cake obtained was dried in vacuo and used directly in the next example.

Workup

  1. temperatureat reflux for 18 hours
  2. filtrationfiltered
  3. filtrationThe solid filter cake
  4. customobtained
  5. customwas dried in vacuo

Sources & evidence

ORD record
ord-9c5abeadf0f5455a86ddf472e458a7d2
Source dataset
uspto-grants-1999_06
Patent number
US05908840

Reaction notes

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