Diethyl Ether → HCID 178437756, compound

Participants

Reaction Steps

A slurry of 2-aminoquinoline-3-carboxamide (1.0 g, 5.3 mmol), (Campaigne, E.; Randau, G. J. Het. Chem. 1971, Vol. 8, p. 111) and p-toluenesulfonic acid-monohydrate (50 mg) in triethyl orthopropionate (25 mL) was refluxed for 24 hours. After cooling, the reaction mixture was diluted into diethyl ether (50 mL), the resulting solids filtered and washed with diethyl ether. The solids were recrystallized from formamide to afford 0.14 g of the title compound; m.p. 240-245° C.

Provenance & Evidence