反应详情

A slurry of 2-aminoquinoline-3-carboxamide (1.0 g, 5.3 mmol), (Campaigne, E.; Randau, G. J. Het. Chem. 1971, Vol. 8, p. 111) and p-toluenesulfonic acid-monohydrate (50 mg) in triethyl orthopropionate (25 mL) was refluxed for 24 hours. After cooling, the reaction mixture was diluted into diethyl ether (50 mL), the resulting solids filtered and washed with diethyl ether. The solids were recrystallized from formamide to afford 0.14 g of the title compound; m.p. 240-245° C.

1. temperatureAfter cooling
2. filtrationthe resulting solids filtered
3. washwashed with diethyl ether
4. customThe solids were recrystallized from formamide