Trimethylsilyl cyanide → alpha-(4-Methylanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

HRID 1415777Notes

Reaction equation

HRID 1415777 reaction equation
[S:1]([C:5]1[CH:19]=[CH:18][C:8]([CH:9]=[N:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])(=[O:3])[NH2:2].C[Si]([C:24]#[N:25])(C)C>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][CH:9]([C:8]2[CH:7]=[CH:6][C:5]([S:1](=[O:3])(=[O:4])[NH2:2])=[CH:19][CH:18]=2)[C:24]#[N:25])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 82115Trimethylsilyl cyanideHCID 21862824N-(4-Sulfamoylbenzylidene)-4-methylaniline

Product 1

HCID 21862835alpha-(4-Methylanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

Procedure

Following a procedure similar to that described in Example 1(ii), but using N-(4-sulfamoylbenzylidene)-4-methylaniline [prepared as described in step (i) above] and trimethylsilyl cyanide as starting materials, the title compound was obtained as a pale yellow powder (yield 60%).

Sources & evidence

ORD record
ord-3c8ea00a985d478c8e9691eab78f65c9
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

Loading…