Methacrolein → 2-(3-Fluoro-4-methoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

HRID 1415804Notes

Reaction equation

HRID 1415804 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:16][CH:15]=2)[C:11]#N)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O=[CH:25][C:26](=C)[CH3:27]>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:16][CH:15]=3)[CH:25]=[C:26]([CH3:27])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 6562MethacroleinHCID 21862797alpha-(3-Fluoro-4-methoxyphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

Product 1

HCID 218627722-(3-Fluoro-4-methoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(3-fluoro-4-methoxyphenyl)-α-(4-sulfamoylanilino) acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a white powder (yield 28%), melting at 170-173° C.

Sources & evidence

ORD record
ord-f0c048e2e47d4bc8b250b3f13ad2df76
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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