Methacrolein → 1-(2,4-Difluorophenyl)-4-methyl-2-(4-sulfamoylphenyl)pyrrole

HRID 1415813Notes

Reaction equation

HRID 1415813 reaction equation
[F:1][C:2]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:3]=1[NH:4][CH:5]([C:8]1[CH:13]=[CH:12][C:11]([S:14](=[O:17])(=[O:16])[NH2:15])=[CH:10][CH:9]=1)[C:6]#N.O=[CH:24][C:25](=C)[CH3:26]>>[F:1][C:2]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:3]=1[N:4]1[CH:24]=[C:25]([CH3:26])[CH:6]=[C:5]1[C:8]1[CH:13]=[CH:12][C:11]([S:14](=[O:17])(=[O:16])[NH2:15])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 6562MethacroleinHCID 21862810alpha-(2,4-Difluoroanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

Product 1

HCID 218627851-(2,4-Difluorophenyl)-4-methyl-2-(4-sulfamoylphenyl)pyrrole

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(2,4-difluoroanilino)-α-(4-sulfamoylphenyl)acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a white powder (yield 63%), melting at 140-141° C.

Sources & evidence

ORD record
ord-4a3d9fbdba4d4f0383e4b5b963ab2c06
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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